Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H 3 antagonist and serotonin transporter inhibitors

JM Keith, LA Gomez, AJ Barbier, SJ Wilson…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4374 - 4377

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Citation Number: 24

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... In the current paper, we describe a medicinal chemistry effort to synthesize molecules combining H 3 receptor antagonism ... We warmly thank Bruce E. Maryanoff for helpful discussions regarding the described chemical series and Steve ...