Synlett

Total synthesis of the marine-derived cyclic depsipeptide alternaramide

AE Horton, OS May, MRJ Elsegood, MC Kimber

Index: Horton, Alexandra E.; May, Oliver S.; Elsegood, Mark R. J.; Kimber, Marc C. Synlett, 2011 , # 6 p. 797 - 800

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Citation Number: 5

Abstract

Abstract The first synthesis of the marine fungus derived natural product alternaramide is described using solution phase coupling protocols and via a macrolactonization and macrolactamization route. The structure of alternaramide was confirmed and was supported by single crystal X-ray analysis which exhibited three similar molecules in the asymmetric unit, each with transannular hydrogen bonds.

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