Tetrahedron

4-(4, 6-dimethoxy-1, 3, 5-triazin-2-yl)-4-methyl-morpholinium chloride: an efficient condensing agent leading to the formation of amides and esters

M Kunishima, C Kawachi, J Monta, K Terao, F Iwasaki…

Index: Kunishima, Munetaka; Kawachi, Chiho; Morita, Jun; Terao, Keiji; Iwasaki, Fumiaki; Tani, Shohei Tetrahedron, 1999 , vol. 55, # 46 p. 13159 - 13170

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Citation Number: 339

Abstract

4-(4, 6-Dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) was quantitatively synthesized by the coupling of 2-chloro-4, 6-dimethoxy-1, 3, 5-triazine (CDMT) and N-methylmorpholine (NMM) in THF, and characterized. Condensation of carboxylic acids and amines by DMTMM proceeded effectively in THF to give the corresponding amides in good yields. The corresponding esters can be obtained by esterification of ...

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