Studies related to cephalosporins. Part 2. Displacement reactions on 3??bromomethylcephems with salts of carboxylic acids

M Botta, F De Angelis, I Grgurina…

Index: Botta; De Angelis; Grgurina; et al. Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1001 - 1007

Full Text: HTML

Citation Number: 5

Abstract

Abstract The reactivity of Δ 3-and Δ 2-3-bromomethylcephems toward carboxylate nucleophiles has been studied. The Δ 3-bromomethylcephem 1, less reactive than the Δ 2- analogue 4, is converted in high yields into 3-acyl-oxymethyl-3-cephems 2a-d, generally with no isomerization of the double bond, only within a narrow range of conditions. In particular, the Δ 3-7-aminocephalosporanic acid (7-ACA) derivative 2a has been obtained ...

Related Articles:

meta-Substituted benzamide oligomers that complex mono-, di-and tricarboxylates: folding-induced selectivity and chirality

[Organic and Biomolecular Chemistry, , vol. 9, # 23 p. 8122 - 8129]

Glycosylation using a one-electron-transfer, homogeneous reagent. Application to an efficient synthesis of the trimannosyl core of N-glycosylproteins

[Zhang, Yong-Min; Mallet, Jean-Maurice; Sinay, Pierre Carbohydrate Research, 1992 , vol. 236, p. 73 - 88]

More Articles...