Derivatives of 11-(1-piperazinyl)-5H-pyrrolo [2, 1-c][1, 4] benzodiazepine as central nervous system agents

…, EN Greenblatt, IP Day, NQ Quinones…

Index: Wright, William B.; Greenblatt, Eugene N.; Day, Ivana P.; Quinones, Nicanor Q.; Hardy, Robert A. Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 462 - 465

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Citation Number: 27

Abstract

Four ll-(l-piperazinyl)-5H-pyrrolo [2, 1-c][1, 4] benzodiazepines were prepared and evaluated as central nervous system agents. All were active psychotropic agents as determined by animal screening tests. The most interesting compound, 1 l-(l-piperazinyl)-5H- pyrrolo [2, 1-c][1, 4] benzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. ...