Syntheses of 6-Deaminosinefungin and (S)-6-Methyl-6-deaminosinefungin

P Peterli-Roth, MP Maguire, E Leon…

Index: Peterli-Roth; Maguire; Leon; Rapoport Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4186 - 4193

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Citation Number: 19

Abstract

The nucleosides S-adenosylmethionine (SAM, AdoMet) and S-adenosylhomocysteine (SAH, AdoHcy) are involved in a number of important enzyme systems. The direct or indirect inhibition of these enzymes is currently of high interest, particularly in the areas of antiviral and cell proliferation research. We report here the first chirospecific syntheses of 6 (S)- methyl-6-deaminosinefungin (4) and 6-deaminosinefungin (6) which are analogues of ...

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