Synthesis of [18F]-labeled (6-fluorohexyl) triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomography

DY Kim, HJ Kim, KH Yu, JJ Min

Index: Kim, Dong-Yeon; Kim, Hee-Jung; Yu, Kook-Hyun; Min, Jung-Joon Bioconjugate Chemistry, 2012 , vol. 23, # 3 p. 431 - 437

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Citation Number: 22

Abstract

Lipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes and accumulate in mitochondria in response to the negative inner-transmembrane potentials. Thus, as newly developed noninvasive imaging agents,[18F]-labeled phosphonium salts may serve as molecular “voltage sensor” probes to investigate the role of mitochondria, particularly in myocardial disease. The present study ...