Tetrahedron

Synthesis of isoquinolines from 2-phenylethylamines, amides, nitriles and carboxylic acids in polyphosphoric acid

AP Venkov, II Ivanov

Index: Venkov, Atanas P.; Ivanov, Ilian I. Tetrahedron, 1996 , vol. 52, # 37 p. 12299 - 12308

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Citation Number: 38

Abstract

A convenient one pot synthesis of 1-. 1.3-substituted 3.4-dihydroisoquinolines 5. enamines 10 and 3-oxo-2, 3-dihydroisoquinolines 18 as well as of enamides 22 of isoquinoline from 2- phenyl-. 1, 2-diphenylethylamines, phenylacetamides, phenylacetonitriles, N- acylphenylethyl-amines and carboxylic acids in nonaqueous media has been accomplished.

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