Organic & biomolecular chemistry

A facile approach to highly functional trisubstituted furans via intramolecular Wittig reactions

KW Chen, S Syu, YJ Jang, W Lin

Index: Chen, Ko-Wei; Syu, Siang-En; Jang, Yeong-Jiunn; Lin, Wenwei Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2098 - 2106

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Citation Number: 29

Abstract

An efficient and mild synthesis of trisubstituted furans, starting from α, β-unsaturated ketones, tributylphosphine, and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to install the crucial furan ring, leading to a wide variety of highly functional furans in one step.

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