Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid

L Zhang, Y Zhang, J Dong, J Liu, L Zhang…

Index: Zhang, Liying; Zhang, Yingxia; Dong, Jizhe; Liu, Jun; Zhang, Luyong; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1036 - 1039

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Citation Number: 11

Abstract

To explore the molecular mechanisms of oleanolic acid, two novel photoaffinity probes were synthesized based on the structure–activity relationship reported previously. Their potency were evaluated in an enzyme inhibition assay against rabbit muscle glycogen phosphorylase a (RMGPa), a known target protein of oleanolic acid. The inhibitory activity of probe 2 was only about two-fold less potent than the mother compound oleanolic acid. ...