2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor

…, O Pontiggia, M Simian, JM Montserrat…

Index: Pontiggia, Rodrigo; Pontiggia, Osvaldo; Simian, Marina; Montserrat, Javier M.; Engels, Joachim W.; Iribarren, Adolfo M. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2806 - 2808

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Abstract

A new synthesis of 2′-C-methyluridine phosphoramidite is presented. Special emphasis is dedicated to the improvement of the protection of the tertiary 2′-hydroxyl group. Comparison to previous protecting strategies and analysis of stability under 5′-DMTr removing conditions are discussed. The synthetic incorporation of this modified nucleoside into the catalytic core of a hammerhead ribozyme against the estrogen receptor α protein ( ...

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