Discovery of novel 6, 7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene) pyrimidine-2, 4, 6-trione moiety as c-Met kinase inhibitors

…, R Li, H Lin, P Li, M Cheng, P Gong, Y Zhao

Index: Tang, Qidong; Zhang, Guogang; Du, Xinming; Zhu, Wufu; Li, Ruijuan; Lin, Huafang; Li, Pengcheng; Cheng, Maosheng; Gong, Ping; Zhao, Yanfang Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1236 - 1249

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Citation Number: 12

Abstract

Abstract A series of novel quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2, 4, 6-trione moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 5 cancer cell lines (HT-29, H460, MKN-45, A549, and U87MG) in vitro. Most compounds showed moderate to excellent potency, with the most promising analogue 45 (c-Met half-maximal inhibitory concentration [IC 50]= 1.15 ...