Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins

T Noonan, N Brown, L Dudycz…

Index: Noonan, Timothy; Brown, Neal; Dudycz, Lech; Wright, George Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1302 - 1307

Full Text: HTML

Citation Number: 25

Abstract

Interaction of GTP Derivatives with ras-p2l Proteins tivity of the protein, and activate, in rod outer segments, the cyclicGMP phosphodiesterase that is the intracellular" targetw of the transducin-GTP complex. lS Therefore, we synthesized a series of N2-substituted GTPs, and, in this paper, describe the ability of these and other GTP derivatives to bind to ras-pel proteins.