Total synthesis of lactacystin

EJ Corey, GA Reichard

Index: Corey; Reichard, Gregory A. Journal of the American Chemical Society, 1992 , vol. 114, # 26 p. 10677 - 10678

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Citation Number: 164

Abstract

Lactacystin (1) is a novel microbial product which was identified by Omura et al. after screening several thousand culture samples for the capacity to induce differentiation in a neuroblastoma cell line.'-* The great current interest in neurotrophic proteins, eg, nerve growth factor, as therapeutic agents and neuroscience research tools3” and the scarcity of 1 encouraged us to undertake the synthesis which is described herein. The availability of ...

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