Synthesis and antimicrobial activity of 2-fluorophenyl-4, 6-disubstituted [1, 3, 5] triazines

…, V Perron, C Lauzon, C Penney, B Zacharie

Index: Saleh, Mona; Abbott, Shaun; Perron, Valerie; Lauzon, Caroline; Penney, Christopher; Zacharie, Boulos Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 945 - 949

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Citation Number: 39

Abstract

A series of 2-fluorophenyl-4, 6-disubstituted [1, 3, 5] triazines (1) and (2) were synthesized and evaluated for their antimicrobial activity against three representative gram-positive bacteria and two fungi. The structure–activity relationship (SAR) demonstrates that the 3-or 4- fluorophenyl component attached directly to the triazine ring was essential for activity. Of these compounds, 14, 15, and 25 demonstrated significant activity against all selected ...