Organic letters

Synthesis of Spirotetramates via a Diels− Alder Approach

NA Butt, CJ Moody

Index: Moody, Christopher J.; Ward, John G. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 12 p. 2903 - 2909

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Citation Number: 6

Abstract

A study toward the unusual spirotetramate core of the pyrroindomycin antibiotics employing an intermolecular Diels− Alder reaction of an exo-methylene tetramic acid dienophile is described. The exo-methylene tetramate is readily synthesized from S-methylcysteine, and