Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene) thiazolidine-2, 4-dione that improve selectivity for inhibiting the proliferation of melanoma cells …

KY Jung, R Samadani, J Chauhan, K Nevels…

Index: Jung, Kwan-Young; Samadani, Ramin; Chauhan, Jay; Nevels, Kerrick; Yap, Jeremy L.; Zhang, Jun; Worlikar, Shilpa; Lanning, Maryanna E.; Chen, Lijia; Ensey, Mary; Shukla, Sagar; Salmo, Rosene; Heinzl, Geoffrey; Gordon, Caryn; Dukes, Troy; MacKerell Jr., Alexander D.; Shapiro, Paul; Fletcher, Steven Organic and Biomolecular Chemistry, 2013 , vol. 11, # 22 p. 3706 - 3732

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Citation Number: 6

Abstract

We herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene) thiazolidine-2, 4-dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling.

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