Base-free two-step synthesis of 1, 3-diketones and β-ketoesters from α-diazocarbonyl compounds, trialkylboranes, and aromatic aldehydes

MA Sanchez-Carmona, DA Contreras-Cruz…

Index: Sanchez-Carmona, Miguel A.; Contreras-Cruz, David A.; Miranda, Luis D. Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6506 - 6508

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Abstract

We describe a convergent, base-free two-step synthesis of 1, 3-diketones and β-ketoesters from α-diazocarbonyl compounds, trialkylboranes, and aromatic aldehydes in a three- component process. The synthetic potential of this protocol was underscored by the synthesis of several symmetrical 1, 3, 5-triaryl-4-alkyl and 1, 3, 4, 5-tetraryl substituted pyrazoles in a three-step sequence.

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