The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive …

…, KA Youdim, MZ Qaiser, C Rice??Evans…

Index: Kavvadias, Dominique; Sand, Philipp; Youdim, Kuresh A.; Qaiser, M. Zeeshan; Rice-Evans, Catherine; Baur, Roland; Sigel, Erwin; Rausch, Wolf-Dieter; Riederer, Peter; Schreier, Peter British Journal of Pharmacology, 2004 , vol. 142, # 5 p. 811 - 820

Full Text: HTML

Citation Number: 142

Abstract

2 After chemical synthesis, hispidulin was investigated at recombinant GABAA/BZD receptors expressed by Xenopus laevis oocytes. Concentrations of 50nM and higher stimulated the GABA-induced chloride currents at tested receptor subtypes (a1À3, 5, 6b2g2S) indicating positive allosteric properties. Maximal stimulation at a1b2g2S was observed with 10 mM hispidulin. In contrast to diazepam, hispidulin modulated the ...