Synthesis of Pyrryl Aryl Sulfones Targeted at the HIV??1 Reverse Transcriptase

…, F Scintu, E Pinna, E Tinti, P La Colla

Index: Artico; Silvestri; Stefancich; Massa; Pagnozzi; Musu; Scintu; Pinna; Tinti; La Colla Archiv der Pharmazie, 1995 , vol. 328, # 3 p. 223 - 229

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Citation Number: 37

Abstract

Abstract Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1, 2- Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitrophenyl phenyl sulfone).