Identification of Ligand-Binding Regions of P-Glycoprotein by Activated-Pharmacophore Photoaffinity Labeling and Matrix-Assisted Laser Desorption/Ionization–Time- …

GF Ecker, E Csaszar, S Kopp, B Plagens, W Holzer…

Index: Molecular Pharmacology, , vol. 61, # 3 p. 637 - 648

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Citation Number: 54

Abstract

... represents one possible experimental strategy to characterize those regions of the protein molecule in which an interaction with low-molecular-mass ligands takes ... that R influences pharmacological activity solely by its contribution to overall lipophilicity of the molecules. ...

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