Synthesis based on affinity separation (SAS): separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction

SQ Zhang, K Fukase, M Izumi, Y Fukase, S Kusumoto

Index: Zhang, San-Qi; Fukase, Koichi; Izumi, Minoru; Fukase, Yoshiyuki; Kusumoto, Shoichi Synlett, 2001 , # 5 p. 590 - 596

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Citation Number: 20

Abstract

Abstract: A new method is described for affinity purification of synthetic compounds based on molecular recognition between bis (2, 6-diaminopyridine) amide of isophthalic acid and a barbituric acid derivative. The desired compounds possessing the barbituric acid derivative as a tag were readily isolated from the reaction mixture by the following procedure. After each reaction cycle, the reaction mixture was applied to the polystyrene column ...