Convenient practical resolution of racemic alkyl-aryl alcohols via enzymatic acylation with succinic anhydride in organic solvents

AL Gutman, D Brenner, A Boltanski

Index: Gutman, Arie L.; Brenner, Dov; Boltanski, Aviv Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 839 - 844

Full Text: HTML

Citation Number: 72

Abstract

Abstract Enantiomerically pure alkyl-aryl secondary alcohols were conveniently obtained on a kilogram scale from their racemic mixtures by enzymatic acylation with succinic anhydride in organic solvents. A major advantage of this acylation method is the ease of separating the ester from the unreacted alcohol. This is achieved by extracting the organic solution with aqueous NaHCO 3 after the enzymatic reaction is completed.