Modulation of the Cs 2 CO 3-promoted catalytic amination by a crown ether

Y Torisawa, T Nishi, J Minamikawa

Index: Torisawa; Nishi; Minamikawa Bioorganic and medicinal chemistry letters, 2000 , vol. 10, # 21 p. 2489 - 2491

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Citation Number: 8

Abstract

The catalytic addition of 18-Crown-6 in some Cs2CO3-promoted amination of triflates and bromides was beneficial to improve sluggish reaction with suppression of the unwanted side products. The protocol was useful for the preparation of chlorinated aryl piperazines from phenol derivatives.