Facile synthesis of deuterated and [14C] labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools

…, LA Graham, C Schneider

Index: Gordon, Odaine N.; Graham, Leigh A.; Schneider, Claus Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 14 p. 696 - 699

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Citation Number: 4

Abstract

Curcumin is a dietary diphenol with antioxidant, antinflammatory, and antitumor activity. We describe facile procedures for the synthesis of [14C2] curcumin (4mCi/mmol),[d6] curcumin,[d3] curcumin,[13C5] curcumin, and [d6] bicyclopentadione, the major oxidative metabolite of curcumin. We also describe synthesis of the labeled building blocks [14C] vanillin,[d3] vanillin, and [13C5] acetylacetone. The overall molar yields of the labeled ...

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