Synthesis of (+)-avermectin B1a

S Hanessian, A Ugolini, D Dube…

Index: Hanessian; Ugolini; Dube; et al. Journal of the American Chemical Society, 1986 , vol. 108, # 10 p. 2776 - 2778

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Citation Number: 95

Abstract

OH strategy is based on a stereospecific total synthesis of the" northern" C,]-CZ8 segment utilizing chirons derived from (S)-malic acid and L-isoleucine followed by coupling with a suitably functionalized" southern" segment, macrolactonization, stereocontrolled glycosylation, and adjustment of functionality. The allylic alcohol 2,[a] D 35.2', easily obtained from 1 via~-isoleucine,'was transformed into the six-carbon chiron 3,[(Y] D-67.3', ...

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