Diazotisation Mechanism of Heteroaromatic Amines. Diazotisation of 2??aminothiazole as an equilibrium

…, B Güleç, P Skrabal, H Zollinger

Index: Diener, Heinz; Guelec, Bilge; Skrabal, Peter; Zollinger, Heinrich Helvetica Chimica Acta, 1989 , vol. 72, p. 800 - 805

Full Text: HTML

Citation Number: 9

Abstract

Abstract The rate of diazotization of 2-aminothiazole was measured in 65 to 75%(w/w) aqueous H 2 SO 4. The kinetic solvent isotope effect of the diazotization in 72% D 2 SO4/D 2 O was determined (k H/k D= 5.8±0.2). These data are consistent with a mechanism in which the 2-aminothiazole, protonated at the ring N-atom, but not at the NH 2 group, is attacked by the NO+ ion. The reaction does not go to completion, but to an equilibrium. The ...

Related Articles:

Amination of aryl halides using copper catalysis

[Lang, Fengrui; Zewge, Daniel; Houpis, Ioannis N.; Volante Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3251 - 3254]

Synthesis of 2-(aminoacetylamino) thiazole derivatives and comparison of their local anaesthetic activity by the method of action potential

[Geronikaki; Theophilidis European Journal of Medicinal Chemistry, 1992 , vol. 27, # 7 p. 709 - 716]

Synthesis and Characterization of New Compounds containing 2-amino Thiazole Ring from Amino Benzoic Acid

[Karpov; Nazarenko; Pekarevskii; Potekhin Russian Journal of Applied Chemistry, 2001 , vol. 74, # 6 p. 998 - 1001]

Hydrolysis of imines. 4. Micellar effects upon the spontaneous acid, base, and copper (II) ion induced hydrolysis of N-salicylidene-2-aminothiazole and N-salicylidene- …

[Journal of Organic Chemistry, , vol. 50, # 16 p. 2905 - 2910]

Discovery of novel N-(5-(arylcarbonyl) thiazol-2-yl) amides and N-(5-(arylcarbonyl) thiophen-2-yl) amides as potent RORγt inhibitors

[Bioorganic and Medicinal Chemistry, , vol. 22, # 2 p. 692 - 702]

More Articles...