Tetrahedron letters

Quinonoid dihydrobiopterin, an important metabolic intermediate of biopterin cofactor in the aromatic hydroxylation of amino acids

S Matsuura, S Murata, T Sugimoto

Index: Matsuura, Sadao; Murata, Shizuaki; Sugimoto, Takashi Tetrahedron Letters, 1986 , vol. 27, # 5 p. 585 - 588

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Citation Number: 4

Abstract

In the biosynthesis of neurotransmitting catecholamines, the hydroxylation of phenylalanine and tyrosine requires(6R)-5, 6, 7, 8_tetrahydrobiopterin (1) as the natural cofactor. 1 During the enzymatic reactions, 1 is oxidized to quinonoid (6R)-dihydrobiopterin(2), which is reduced back to 1 by dihydropterin reductase and NADPH (or NADH). la In the absence of such recycling pathway, 2 will spontaneously isomerize to thermodynamically more stable ...