Design of PAP-1, a selective small molecule Kv1. 3 blocker, for the suppression of effector memory T cells in autoimmune diseases

A Schmitz, A Sankaranarayanan, P Azam…

Index: Molecular Pharmacology, , vol. 68, # 5 p. 1254 - 1270

Full Text: HTML

Citation Number: 138

Abstract

... The first small molecules that were found to inhibit the Kv channel in human T cells ... companies started screening their libraries for more potent and more selective small molecule Kv1.3 ... Wulff et al., 2003a), which are of a relatively simple structure and low molecular weight and ...