The Journal of Organic Chemistry

A practical chemoenzymic synthesis of the taxol C-13 side chain N-benzoyl-(2R, 3S)-3-phenylisoserine

DM Gou, YC Liu, CS Chen

Index: Gou, Da-Ming; Liu, Yeuk-Chuen; Chen, Ching-Shih Journal of Organic Chemistry, 1993 , vol. 58, # 5 p. 1287 - 1289

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Citation Number: 150

Abstract

Taxol (l), an antimicrotubule agent isolated from the bark of Taxus brevifolia,'has recently attracted much attantion because of its efficacy in the treatment of various types of cancer. 2 One major impediment to the wide use of tax01 in cancer chemotherapy is its extremely limited availability. Also, chemical complexity has prohibited the commercial production of 1 by total~ ynthesis.~ Thus, a viable approach for the preparation of 1 is to utilize more ...

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