Journal of the Chinese Chemical Society

Chemo??Enzymatic Synthesis of Optically Active Amino Acids and Peptides

ST Chen, KT Wang

Index: Chen, Shui-Tein; Wang, Kung-Tsung Journal of the Chinese Chemical Society, 1999 , vol. 46, # 3 p. 301 - 311

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Citation Number: 9

Abstract

Abstract The industrial alkaline protease, alcalase, is stable and active in a high concentration of organic solvents and useful as a biocatalyst for (i) diastereoselective hydrolysis of peptide esters and preparation of racemization-free peptides;(ii) selective incorporation of esters of D-amino acid into peptides in t-butanol via a selective hydrolysis of esters of D, L-amino acid, followed by using the unhydrolyzed D-esters as a nucleophile in ...

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