Esterification of five-membered cyclic phosphinic acids under mild conditions using propylphosphonic anhydride (T3P®)

E Jablonkai, M Milen, L Drahos, G Keglevich

Index: Jablonkai, Erzsebet; Milen, Matyas; Drahos, Laszlo; Keglevich, Gyoergy Tetrahedron Letters, 2013 , vol. 54, # 44 p. 5873 - 5875

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Citation Number: 14

Abstract

Phosphinates are usually synthesized by the reaction of phosphinic chlorides with alcohols (Scheme 1A). 1 This method works well, but it utilizes rather expensive chlorides and cannot be regarded as being environmentally friendly due to the formation of hydrochloric acid. It is well-known that phosphinic acids do not undergo direct esterification with alcohols on conventional heating (Scheme 1B). However, under microwave irradiation, direct esterification of ...