Uncatalyzed Three??Component Synthesis of α??Hydrazido Phosphonates

…, D Roca??López, G Navarro??Moros

Index: Herrera, Raquel P.; Roca-Lopez, David; Navarro-Moros, Gloria European Journal of Organic Chemistry, 2010 , # 8 p. 1450 - 1454

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Abstract

Abstract Various α-hydrazido phosphonates have been easily prepared on the basis of the nucleophilic addition of diphenyl phosphite to reactive, preformed N-acylhydrazones and a three-component (aldehydes, N-benzoylhydrazide and diphenyl phosphite) coupling reaction through a non-catalyzed process. An unprecedented and promising enantioselective example of this reaction is also reported.