Ring expansion of benzocyclic ketones via transient alkoxyl radicals: The side chain incorporation approach

WR Bowman, PJ Westlake

Index: Bowman, W. Russell; Westlake, Paul J. Tetrahedron, 1992 , vol. 48, # 19 p. 4027 - 4038

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Citation Number: 51

Abstract

Radical cyclisation onto carbonyl groups followed by β-sission of the resulting alkoxy radicals provides a method for the one-carbon ring expansion of benzocyclic ketones. The radicals are generated by Bu3SnH reduction of bromomethyl moieties α to the carbonyl group of benzocyclic ketones.