Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones

NK Konduru, S Dey, M Sajid, M Owais…

Index: Konduru, Naveen Kumar; Dey, Sunita; Sajid, Mohammad; Owais, Mohammad; Ahmed, Naseem European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 23 - 30

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Citation Number: 32

Abstract

Two series of chalcone based sulfone and bisulfone derivatives were synthesized using chalcone, thiophenol and sodium metal at room temperature, followed by oxidation of chalcone sulfides with m-CPBA at 0° C in a novel method. Both sulfones and bisulfones were evaluated for their antimicrobial activities against Aspergillus niger and Candida albicans (yeast), Bacillus subtilis and Staphylococcus aureus (Gram (+) bacteria) and ...