Tetrahedron letters

A novel synthesis of functionalized ketones via a nickel-catalyzed coupling reaction of zinc reagents with thiolesters

T Shimizu, M Seki

Index: Shimizu, Toshiaki; Seki, Masahiko Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1039 - 1042

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Citation Number: 46

Abstract

The transformation of carboxylic acids into ketones has received considerable attention because of its significance in synthetic organic chemistry. 1 As most of the target molecules have functional groups, a methodology, which permits the synthesis of the functionalized ketones without the use of protection–deprotection sequence as well as functional group transformations, has been highly desirable. Among the organometallic compounds, organozinc reagents 2., , and ...