Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity

C Changtam, P Hongmanee, A Suksamrarn

Index: Changtam, Chatchawan; Hongmanee, Poonpilas; Suksamrarn, Apichart European Journal of Medicinal Chemistry, 2010 , vol. 45, # 10 p. 4446 - 4457

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Citation Number: 71

Abstract

Curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), the curcuminoid constituents of the medicinal plant Curcuma longa L., have been structurally modified to 55 analogs and antimycobacterial activity against Mycobacterium tuberculosis has been evaluated. Among the highly active curcuminoids, the isoxazole analogs are the most active group, with mono-O-methylcurcumin isoxazole (53) being the most active compound (MIC ...

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