Hexahydrocurcumin

Modify Date: 2025-08-26 19:35:11

Hexahydrocurcumin Structure
Hexahydrocurcumin structure
 Common Name Hexahydrocurcumin
CAS Number 36062-05-2 Molecular Weight 374.427
Density 1.2±0.1 g/cm3 Boiling Point 622.6±55.0 °C at 760 mmHg
Molecular Formula C21H26O6 Melting Point 80-82℃
MSDS Chinese USA Flash Point 218.4±25.0 °C

 Use of Hexahydrocurcumin


Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities; selective COX-2 inhibitor.IC50 value:Target: in vitro: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays [1]. HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. HHC significantly down-regulates COX-2 mRNA expression compared to the control (control: 100.05% ± 0.03% vs HHC: 61.01% ± 0.35%, P < 0.05) but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy [2].in vivo: The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression in rats [3].

 Names

Name Hexahydrocurcumin
Synonym More Synonyms

 Hexahydrocurcumin Biological Activity

Description Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities; selective COX-2 inhibitor.IC50 value:Target: in vitro: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays [1]. HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. HHC significantly down-regulates COX-2 mRNA expression compared to the control (control: 100.05% ± 0.03% vs HHC: 61.01% ± 0.35%, P < 0.05) but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy [2].in vivo: The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression in rats [3].
Related Catalog
References

[1]. Li F, et al. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem. 2012 Nov 15;135(2):332-7.

[2]. Srimuangwong K, et al. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9.

[3]. Srimuangwong K, et al. Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats. World J Gastroenterol. 2012 Dec 21;18(47):6951-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 622.6±55.0 °C at 760 mmHg
Melting Point 80-82℃
Molecular Formula C21H26O6
Molecular Weight 374.427
Flash Point 218.4±25.0 °C
Exact Mass 374.172943
PSA 96.22000
LogP 1.49
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.583
Storage condition -20°C

 Safety Information

RIDADR NONH for all modes of transport
HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 HexahydrocurcuminBioassay

View more

Name: Neuroprotective activity against glutamate-induced excitotoxicity in rat PC12 cells a...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5389940
Name: Neuroprotective activity against glutamate-induced excitotoxicity in rat PC12 cells a...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5389939
Name: Neuroprotective activity against glutamate-induced excitotoxicity in rat PC12 cells a...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5389938
Name: Positive allosteric modulation of GluN1/N2B (unknown origin) transfected in HEK293 ce...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2B
External Id: CHEMBL5389935
Name: Positive allosteric modulation of GluN1/N2A (unknown origin) transfected in HEK293 ce...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2A
External Id: CHEMBL5389934
Name: Inhibition of recombinant BACE1 (unknown origin) at 1.3 mM
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL3107153
Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data
Name: Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 24 hrs by m...
Source: ChEMBL
Target: Mycobacterium tuberculosis
External Id: CHEMBL1252095
Name: Antitrypanosomal activity against multidrug-resistant Trypanosoma brucei brucei B48 a...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL1099526
Name: Antitrypanosomal activity against diminazene-resistant Trypanosoma brucei brucei delt...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL1099525
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 Synonyms

Hexahydrocurcumin
5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one
5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone
(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone
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