Hexahydrocurcumin
Hexahydrocurcumin structure
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Common Name | Hexahydrocurcumin | ||
|---|---|---|---|---|
| CAS Number | 36062-05-2 | Molecular Weight | 374.427 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 622.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H26O6 | Melting Point | 80-82℃ | |
| MSDS | Chinese USA | Flash Point | 218.4±25.0 °C | |
Use of HexahydrocurcuminHexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities; selective COX-2 inhibitor.IC50 value:Target: in vitro: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays [1]. HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. HHC significantly down-regulates COX-2 mRNA expression compared to the control (control: 100.05% ± 0.03% vs HHC: 61.01% ± 0.35%, P < 0.05) but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy [2].in vivo: The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression in rats [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Hexahydrocurcumin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities; selective COX-2 inhibitor.IC50 value:Target: in vitro: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays [1]. HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. HHC significantly down-regulates COX-2 mRNA expression compared to the control (control: 100.05% ± 0.03% vs HHC: 61.01% ± 0.35%, P < 0.05) but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy [2].in vivo: The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression in rats [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 622.6±55.0 °C at 760 mmHg |
| Melting Point | 80-82℃ |
| Molecular Formula | C21H26O6 |
| Molecular Weight | 374.427 |
| Flash Point | 218.4±25.0 °C |
| Exact Mass | 374.172943 |
| PSA | 96.22000 |
| LogP | 1.49 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.583 |
| Storage condition | -20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2914509090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 1 | |
CAS#:869101-60-0
CAS#:458-37-7
CAS#:36062-04-1
CAS#:147556-16-9
CAS#:121-33-5
CAS#:123-54-6
CAS#:41137-87-5This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Hexahydrocurcumin |
| 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one |
| 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone |
| (RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of Hexahydrocurcumin? |
| A: Melting point of Hexahydrocurcumin is 80-82℃. |
| Q: What are the storage conditions for Hexahydrocurcumin? |
| A: Storage conditions for Hexahydrocurcumin: -20°C. |
| Q: What is the LogP of Hexahydrocurcumin? |
| A: LogP of Hexahydrocurcumin is 1.49. |
| Q: What English synonyms does Hexahydrocurcumin have? |
| A: English synonyms of Hexahydrocurcumin: Hexahydrocurcumin, 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one, 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone, (RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone. |
| Q: What is the boiling point of Hexahydrocurcumin? |
| A: Boiling point of Hexahydrocurcumin is 622.6±55.0 °C at 760 mmHg. |
| Q: What is the CAS number of Hexahydrocurcumin? |
| A: CAS number of Hexahydrocurcumin is 36062-05-2. |
| Q: What are the downstream products of Hexahydrocurcumin? |
| A: Related downstream products(CAS) of Hexahydrocurcumin: 41137-87-5. |
| Q: What are the upstream materials of Hexahydrocurcumin? |
| A: Related upstream materials(CAS) of Hexahydrocurcumin: 869101-60-0;458-37-7;36062-04-1;147556-16-9;121-33-5;123-54-6. |
| Q: What is the polar surface area (PSA) of Hexahydrocurcumin? |
| A: Polar surface area (PSA) of Hexahydrocurcumin is 96.22000. |
| Q: What is the English name of Hexahydrocurcumin? |
| A: The English name of Hexahydrocurcumin is Hexahydrocurcumin. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |