Synlett

Gold-catalyzed synthesis of 2-substituted, 2, 3-disubstituted and 1, 2, 3-trisubstituted indoles in [bmim] BF4

I Ambrogio, A Arcadi, S Cacchi, G Fabrizi, F Marinelli

Index: Ambrogio, Ilaria; Arcadi, Antonio; Cacchi, Sandro; Fabrizi, Giancarlo; Marinelli, Fabio Synlett, 2007 , # 11 p. 1775 - 1779

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Citation Number: 18

Abstract

Abstract Cyclization of 2-alkynylanilines in the presence of NaAuCl 4· H 2 O using [bmim] BF 4 as the reaction medium afforded 2-substituted indoles in high yields. The catalyst system was best recycled using n-Bu 4 NAuCl 4. 2, 3-Disubstituted indoles could be prepared from 2-alkynylanilines and 3-buten-2-one through a one-flask annulation-alkylation sequence and 1, 2, 3-trisubstituted indoles were obtained from the same starting materials via an ...

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