Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein

…, V Lisowski, Y Touati-Jallabe, F Rodier…

Index: Peuchmaur, Marine; Lacour, Marie-Agnes; Sevalle, Jean; Lisowski, Vincent; Touati-Jallabe, Youness; Rodier, Fabien; Martinez, Jean; Checler, Frederic; Hernandez, Jean-Francois Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 1018 - 1029

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Citation Number: 3

Abstract

The 3-alkoxy-7-amino-4-chloro-isocoumarins JLK-6 and JLK-2 have been shown to markedly reduce the production of Amyloid β-peptide (Aβ) by Amyloid-β Precursor Protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor. This suggested that these compounds do not directly inhibit the presenilin-dependent γ-secretase complex but more likely interfere with an ...