Anilinic N??Oxides Support Cytochrome P450??Mediated N??Dealkylation through Hydrogen??Atom Transfer

KM Roberts, JP Jones

Index: Roberts, Kenneth M.; Jones, Jeffery P. Chemistry - A European Journal, 2010 , vol. 16, # 27 p. 8096 - 8107

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Citation Number: 21

Abstract

Abstract The mechanism of N-dealkylation mediated by cytochrome P450 (P450) has long been studied and argued as either a single electron transfer (SET) or a hydrogen atom transfer (HAT) from the amine to the oxidant of the P450, the reputed iron–oxene. In our study, tertiary anilinic N-oxides were used as oxygen surrogates to directly generate a P450- mediated oxidant that is capable of N-dealkylating the dimethylaniline derived from ...