3'-Substituted 2', 3'-dideoxynucleoside analogs as potential anti-HIV (HTLV-III/LAV) agents

P Herdewijn, J Balzarini, E De Clercq…

Index: Herdewijn, Piet; Balzarini, Jan; Clerq, Erik De; Pauwels, Rudi; Baba, Masanori; et al. Journal of Medicinal Chemistry, 1987 ,  vol. 30,  # 8  p. 1270 - 1278

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Citation Number: 338

Abstract

B a, thymin-1-yl (T) 1, c1 b, cytosin-1-yl (C) m, Br c, adenin-9-yl (A) n, I d, uracil-1-yl (U) 0, OMe e, guanin-9-yl (G) P, OEt f, 5-methylcytosin-1-yl q, OCHzCOONa g, 5-ethyluracil-1-yl r, OSOzCH3 h, N4, 5-dimethylcytosin-1-yl s, SEt i, 5-fluorouracil-1-yl t, SCH, CH, OH j, 5- iodouracil-1-yl u, SCN k, N3 also found to be a potent and selective inhibitor of HIV. zO Recently, Lin et al. reported on the antiviral activity of various 3'-azido, 3'-amino, 2', 3'- ...