Tetrahedron

Intramolecular N-aza-amidoalkylation in association with Witkop–Winterfeldt oxidation as the key step to synthesize Luotonin-A analogues

F Pin, S Comesse, A Daïch

Index: Pin, Frederic; Comesse, Sebastien; Daich, Adam Tetrahedron, 2011 , vol. 67, # 31 p. 5564 - 5571

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Citation Number: 19

Abstract

Abstract An expedient four-step approach for the synthesis of a short library of original analogues of the Topo-I Luotonin-A inhibitor, substituted at their C 8-and N 15-positions, was investigated. This consists of Rutaecarpines formation, their Witkop–Winterfeldt oxidation followed ultimately with functional adjustment of the pyrroloquinolone intermediates. In the first step of these investigations, Rutaecarpines including the Topo-I ...

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