Selective synthesis of chlorophosphoramidites using ionic liquids

EJ Amigues, C Hardacre, G Keane, ME Migaud…

Index: Amigues, Eric J.; Hardacre, Christopher; Keane, Gillian; Migaud, Marie E.; Norman, Sarah E.; Pitner, William R. Green Chemistry, 2009 , vol. 11, # 9 p. 1391 - 1396

Full Text: HTML

Citation Number: 13

Abstract

A range of chlorophosphoramidites have been prepared in ionic liquids and compared with material synthesised in molecular solvents. Through the use of ionic liquids as reaction media the moisture sensitivity and impurity issues hampering existing traditional synthetic routes have been eased. Not only can stock chemicals be used without purification, but the reactions may be conducted at room temperature and at high concentrations. Furthermore ...

Related Articles:

Trimethylchlorosilane: a novel activating reagent in nucleotide synthesis via the phosphoramidite route

[Dabkowski, Wojciech; Tworowska, Izabela; Michalski, Jan; Cramer, Friedrich Chemical Communications, 1997 , # 9 p. 877 - 878]

A novel phosphitylating reagent for in situ generation of deoxyribonucleoside phosphoramidites

[Tetrahedron Letters, , vol. 37, # 3 p. 331 - 334]

A novel phosphitylating reagent for in situ generation of deoxyribonucleoside phosphoramidites

[Tetrahedron Letters, , vol. 37, # 3 p. 331 - 334]

β-Cyanoethyl N, N-dialkylamino/N-morpholinomonochloro phosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized …

[Tetrahedron Letters, , vol. 24, # 52 p. 5843 - 5846]

β-Cyanoethyl N, N-dialkylamino/N-morpholinomonochloro phosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized …

[Tetrahedron Letters, , vol. 24, # 52 p. 5843 - 5846]

More Articles...