PREPARATION OF BASE-DEUTERATED 2′-DEOXYADENOSINE NUCLEOSIDES AND THEIR SITE-SPECIFIC INCORPORATION INTO DNA

P Chirakul, JR Litzer, ST Sigurdsson

Index: Chirakul; Litzer; Sigurdsson Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1903 - 1913

Full Text: HTML

Citation Number: 11

Abstract

We report a four-step synthesis of 2′-deoxy-2-deuteroadenosine from 2′-deoxyadenosine in 38% overall yield. The more accessible 2′-deoxy-8-deuteroadenosine was also prepared and incorporated into DNA by automated solid phase synthesis (80% deuterium) using N 6-benzoyl-2′-deoxy-8-deuteroadenosine-3′-O-(2-cyanoethyl-N, N- diisopropylphosphoramidite) in combination with acetyl-protected deoxycytidine and ...

Related Articles:

A designed inhibitor of base-excision DNA repair

[Journal of the American Chemical Society, , vol. 117, # 43 p. 10781 - 10782]

In vitro synthesis of 1, N6??etheno??2′??deoxyadenosine and 1, N2??etheno??2′??deoxyguanosine by 2, 4??dinitrophenol and 1, 3??dinitropyrene in presence of a …

[Environmental Toxicology, , vol. 22, # 2 p. 222 - 227]

PREPARATION OF BASE-DEUTERATED 2′-DEOXYADENOSINE NUCLEOSIDES AND THEIR SITE-SPECIFIC INCORPORATION INTO DNA

[Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1903 - 1913]

Addition of deoxyribose to guanine and modified DNA bases by Lactobacillus helveticus trans-N-deoxyribosylase

[Mueller, Michael; Hutchinson, Linda K.; Peter Guengerich Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1140 - 1144]

More Articles...