Addition of deoxyribose to guanine and modified DNA bases by Lactobacillus helveticus trans-N-deoxyribosylase

…, LK Hutchinson, FP Guengerich

Index: Mueller, Michael; Hutchinson, Linda K.; Peter Guengerich Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1140 - 1144

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Citation Number: 19

Abstract

The use of bacterial trans-N-deoxyribosylase was evaluated as an alternative method for deoxyribosylation in the synthesis of deoxyribonucleosides containing potentially mutagenic adducts. A crude enzyme preparation was isolated from Lactobacillus helveticus and compared to Escherichia coli purine nucleoside phosphorylase. trans-N-deoxyribosylase was more regioselective than purine nucleoside phosphorylase in the deoxyribosylation ...

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