Synthesis of click??reactive HPMA copolymers using RAFT polymerization for drug delivery applications

MF Ebbesen, DH Schaffert, ML Crowley…

Index: Ebbesen, Morten F.; Schaffert, David H.; Crowley, Michael L.; Oupicky, David; Howard, Kenneth A. Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 23 p. 5091 - 5099

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Citation Number: 9

Abstract

ABSTRACT This study describes a versatile strategy combining reversible addition fragmentation transfer (RAFT) polymerization and click chemistry to synthesize well-defined, reactive copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) for drug delivery applications. A novel azide containing monomer N-(3-azidopropyl) methacrylamide (AzMA) was synthesized and copolymerized with HPMA using RAFT polymerization to provide p ( ...