N-(2-HYDROXYPROPYL)METHACRYLAMIDE

Modify Date: 2024-01-05 12:15:51

N-(2-HYDROXYPROPYL)METHACRYLAMIDE Structure
N-(2-HYDROXYPROPYL)METHACRYLAMIDE structure
Common Name N-(2-HYDROXYPROPYL)METHACRYLAMIDE
CAS Number 21442-01-3 Molecular Weight 143.18400
Density 1.002g/cm3 Boiling Point 321.2ºC at 760mmHg
Molecular Formula C7H13NO2 Melting Point 70 °C
MSDS Chinese USA Flash Point 148.1ºC

 Use of N-(2-HYDROXYPROPYL)METHACRYLAMIDE


N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) [1][1].

 Names

Name n-(2-hydroxypropyl)methacrylamide
Synonym More Synonyms

 N-(2-HYDROXYPROPYL)METHACRYLAMIDE Biological Activity

Description N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) [1][1].
Related Catalog
In Vivo At 5 mg/kg body weight drug equivalent dose, all N-(2-Hydroxypropyl)methacrylamide copolymer-drug conjugates which contained lysosomally degradable side chains shows significant in vivo antileishmanial activity (>99% inhibition)[1].
References

[1]. Nan A, et al. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. J Control Release. 2001 Dec 13;77(3):233-43.

[2]. Hao Tang, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese Journal of Polymer Science volume 36, pages1225-1238(2018).

 Chemical & Physical Properties

Density 1.002g/cm3
Boiling Point 321.2ºC at 760mmHg
Melting Point 70 °C
Molecular Formula C7H13NO2
Molecular Weight 143.18400
Flash Point 148.1ºC
Exact Mass 143.09500
PSA 49.33000
LogP 0.45040
Vapour Pressure 2.43E-05mmHg at 25°C
Index of Refraction 1.46

 Safety Information

Risk Phrases 36/37/38
Safety Phrases 26-36/37/39
RIDADR NONH for all modes of transport
HS Code 2924199090

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles4

More Articles
The influence of linker length on the properties of cathepsin S cleavable177Lu-labeled HPMA copolymers for pancreatic cancer imaging

Biomaterials 35(22) , 5760-70, (2014)

N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, ...

Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids.

Biomater. Sci. 3 , 1085-95, (2015)

Many attempts have been made in the application of multicellular tumor spheroids (MCTS) as a 3D tumor model to investigate their biological responses upon introduction of polymeric micelles as nanocar...

Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.

J. Neurosci. 34(35) , 11781-91, (2014)

The vesicular glutamate transporter (VGLUT) plays an essential role in synaptic transmission by filling vesicles with glutamate. At mammalian synapses, VGLUT expression level determines the amount of ...

 Synonyms

1-methacryloylamino-2-hydroxypropane