Phytochemistry

In vitro formation of the anthranoid scaffold by cell-free extracts from yeast-extract-treated Cassia bicapsularis cell cultures

IAM Abdel-Rahman, T Beuerle, L Ernst, AM Abdel-Baky…

Index: Abdel-Rahman, Iman A.M.; Beuerle, Till; Ernst, Ludger; Abdel-Baky, Afaf M.; Desoky, Ezz El-Din K.; Ahmed, Amany S.; Beerhues, Ludger Phytochemistry, 2013 , vol. 88, p. 15 - 24

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Citation Number: 5

Abstract

The anthranoid skeleton is believed to be formed by octaketide synthase (OKS), a member of the type III polyketide synthase (PKS) superfamily. Recombinant OKSs catalyze stepwise condensation of eight acetyl units to form a linear octaketide intermediate which, however, is incorrectly folded and cyclized to give the shunt products SEK4 and SEK4b. Here we report in vitro formation of the anthranoid scaffold by cell-free extracts from yeast-extract-treated ...

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