Physcion

Modify Date: 2025-08-23 12:10:46

Physcion Structure
Physcion structure
 Common Name Physcion
CAS Number 521-61-9 Molecular Weight 284.26
Density 1.4±0.1 g/cm3 Boiling Point 560.5±50.0 °C at 760 mmHg
Molecular Formula C16H12O5 Melting Point 196-206°C
MSDS Chinese USA Flash Point 215.4±23.6 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Physcion


Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

 Names

Name 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Synonym More Synonyms

 Physcion Biological Activity

Description Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].
Related Catalog
Target

IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1] Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1]

References

[1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.

[2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 560.5±50.0 °C at 760 mmHg
Melting Point 196-206°C
Molecular Formula C16H12O5
Molecular Weight 284.26
Flash Point 215.4±23.6 °C
Exact Mass 284.068481
PSA 83.83000
LogP 5.20
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.678
Storage condition -20°C Freezer, Under Inert Atmosphere

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB6720000
CHEMICAL NAME :
Anthraquinone, 1,8-dihydroxy-3-methoxy-6-methyl-
CAS REGISTRY NUMBER :
521-61-9
BEILSTEIN REFERENCE NO. :
1915778
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H12-O5
MOLECULAR WEIGHT :
284.28
WISWESSER LINE NOTATION :
L C666 BV IVJ DQ FO1 LO1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,1342,1979

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CB6720000
HS Code 2914699010

 Synthetic Route

 Customs

HS Code 2914690090
Summary 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles40

More Articles
Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015)

Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two ...

Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

Bioorg. Med. Chem. Lett. 18 , 4106-9, (2008)

As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin deriva...

Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-exposed patients and experimental rats.

Chem. Res. Toxicol. 28 , 1120-32, (2015)

Our prior studies have shown an association between the deaths of children and consumption of Cassia occidentalis (CO) seeds. However, the chemicals responsible for the CO poisoning are not known. The...

 Synonyms

1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Emodin 3-methyl ether
EINECS 208-315-7
MFCD00017374
Emodin monomethyl ether
9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl-
Parietin
Methoxyemodin
1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
Emodin-3-methyl ether
Rheochrysidin
physicion
phycion
1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone
Physcion
1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether
1,8-Dihydroxy-3-methoxy-6-methylanthraquinone
1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone
Physcione
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Chemsrc provides Physcion(CAS#:521-61-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Physcion are included as well.>> amp version: Physcion

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